ProJect Pharmaceutics has developed an innovative process for the liposomal encapsulation of API and manufacturing of drug loaded, lyophilized liposomes.
Particularly adressing processability under standard aseptic conditions, the process is cost effective and GMP compatible. In dedicated laboratories we operate a concept towards high encapsulation and low complexity of manufacturing.
Liposomal encapsulation can be used to enhance solubility, site-specific activity, and pharmacokinetics of many drug products. Our proprietary method to process drug-loaded liposomes is an innovative and straightforward way to manufacture liposomal drug products.
Liposome formulation development for the manufacturing of freeze-dried liposomes is characterized by the following features:
- high entrapment efficiency even for hydrophilic molecules
- compatibility with biomolecules
- GMP-compatible manufacturability with fill&finish standard equipment (mixing / filtration)
- low viscosity with high lipid content
- long-term stable lyophilizate which converts spontaneously into a liposome dispersion at aqueous reconstitution
- based on natural phospholipids (GRAS status)
- charge modification (introduction of negative and positive charges possible)
- unilamellar vesicles (SUVs) for i.v. injection
- multi-lamellar vesicles (LMVs) for s.c. depot